# Veterinary drug interaction checker

> Add two or more drugs and VetMasterJi screens every pair for documented interactions and duplicate therapy, flagging the dangerous combinations — two NSAIDs, an NSAID with a corticosteroid, aminoglycosides with other nephrotoxic drugs — before they reach a prescription. 357 of the 384 monographs carry an interaction list.

Source: https://vetmasterji.com/interactions · Last reviewed: 2026-10-01

## How the check works

- Each monograph lists the drugs and drug classes it interacts with, taken from the drug references.
- For every pair you add, the checker looks for the other drug by name, generic name, brand alias or class (NSAIDs, aminoglycosides, ACE inhibitors, corticosteroids, diuretics, opioids, tetracyclines, macrolides, benzodiazepines, alpha-2 agonists, calcium-containing fluids).
- Matches worded as a contraindication — “do not”, “never”, “fatal”, “avoid” — are flagged red; the rest amber.
- It also flags duplicate therapy: the same drug twice, or two drugs of a high-risk class.

> An assist, not a substitute for clinical judgement: an interaction the references do not document will not be flagged.

## Frequently asked questions

### Can you give meloxicam and prednisolone together in dogs?

Combining an NSAID with a corticosteroid markedly raises the risk of gastrointestinal ulceration and is generally avoided; the interaction checker flags the pair. Allow a washout period when switching between them.

### What does the veterinary interaction checker look for?

Documented drug–drug interactions between any two drugs you add, plus duplicate therapy — the same drug twice, or two drugs from a high-risk class such as two NSAIDs or two sedatives.

## Sources

- Plumb's Veterinary Drug Handbook
- Papich, Papich Handbook of Veterinary Drugs, 5th edition

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VetMasterJi is a clinical decision-support and education platform for veterinary professionals and students. It does not provide veterinary advice, diagnosis or treatment for specific animals. All drug doses, calculators and differentials are references that must be independently verified before clinical use; the attending registered veterinarian remains solely responsible for every clinical decision.