# Vitamin AD3E Injection: veterinary dose and monograph

> Vitamin AD3E Injection is a veterinary drug. Multi-fat-soluble vitamin depot injection for cattle, buffalo, sheep, goat, horses, pigs. Indications include vit A / D / E deficiency prevention in stall-fed / dry-paddock cattle; post-parturient calcium / vitamin metabolism support (alongside calcium); reproductive support — post-AI luteal function adjunct. This monograph lists 6 reference doses for cattle, horses, goats, sheep, pigs and buffalo, each with route, frequency and source, plus meat and milk withdrawal periods for food animals.

Source: https://vetmasterji.com/drugs/vitamin-ad3e-injection · Last reviewed: 2026-10-01

## At a glance

- **Drug class:** Veterinary drug
- **Also known as:** Intavita, Vimeral injection, AD3E Vet
- **Species with doses:** Cattle, Horses, Goats, Sheep, Pigs and Buffalo
- **Routes:** IM
- **Last reviewed:** 1 October 2026

## Indications

- Vit A / D / E deficiency prevention in stall-fed / dry-paddock cattle
- Post-parturient calcium / vitamin metabolism support (alongside calcium)
- Reproductive support — post-AI luteal function adjunct
- Recovery from scours, deworming, or chronic disease
- Pre-monsoon prophylaxis in heavily-stocked feedlots

## Vitamin AD3E Injection dose by species

Doses are per administration unless stated. mg/kg doses scale with body weight; per-animal, per-quarter and infusion-rate doses are shown as the reference writes them.

### Cattle

*Vitamin AD3E Injection doses for cattle*

| Indication | Dose | Route | Frequency | Duration | Withdrawal |
| --- | --- | --- | --- | --- | --- |
| Prophylactic AD3E supplementation | 5 mL per 300 kg deep IM every 30–60 days | IM | q30–60 d | — | Withdrawal NOT established — treat as extra-label |

- Prophylactic AD3E supplementation: Intavita catalogue: 5 mL per 300 kg deep IM. Repeat every 30–60 days. Vimeral syrup PO 50–100 mL daily for 10–14 days as alternative.

### Horses

*Vitamin AD3E Injection doses for horses*

| Indication | Dose | Route | Frequency | Duration |
| --- | --- | --- | --- | --- |
| Adult horse — prophylaxis | 5 mL per adult horse IM | IM | q30–60 d | — |

- Adult horse — prophylaxis: Catalogue: 5 mL per adult horse IM.

### Goats

*Vitamin AD3E Injection doses for goats*

| Indication | Dose | Route | Frequency | Duration | Withdrawal |
| --- | --- | --- | --- | --- | --- |
| Adult goat — prophylaxis | 1–2 mL per adult goat IM | IM | q30–60 d | — | Withdrawal NOT established — treat as extra-label |

- Adult goat — prophylaxis: Catalogue: 1–2 mL per adult goat IM.

### Sheep

*Vitamin AD3E Injection doses for sheep*

| Indication | Dose | Route | Frequency | Duration | Withdrawal |
| --- | --- | --- | --- | --- | --- |
| Adult sheep — prophylaxis | 1–2 mL per adult sheep IM | IM | q30–60 d | — | Withdrawal NOT established — treat as extra-label |

- Adult sheep — prophylaxis: Catalogue: 1–2 mL per adult sheep IM.

### Pigs

*Vitamin AD3E Injection doses for pigs*

| Indication | Dose | Route | Frequency | Duration | Withdrawal |
| --- | --- | --- | --- | --- | --- |
| Adult pig — prophylaxis | 2–5 mL per adult pig IM | IM | q30–60 d | — | Withdrawal NOT established — treat as extra-label |

- Adult pig — prophylaxis: Catalogue: 2–5 mL per adult pig IM.

### Buffalo

*Vitamin AD3E Injection doses for buffalo*

| Indication | Dose | Route | Frequency | Duration | Withdrawal |
| --- | --- | --- | --- | --- | --- |
| Prophylactic AD3E supplementation / fertility support | 5 mL per 300 kg deep IM every 30–60 days | IM | q30–60 d | — | Withdrawal NOT established — treat as extra-label |

- Prophylactic AD3E supplementation / fertility support: Intavita/Vimeral labels buffalo with cattle: 5 mL per 300 kg deep IM q30–60 d, or Vimeral syrup 50–100 mL PO daily ×10–14 d. Used in buffalo for peri-partum support and to correct anoestrus linked to vitamin A/E deficiency.

## Contraindications

Hypervitaminosis A or D (rare in practice). Severe hepatic / renal disease (caution). DO NOT re-inject within 30 days — risk of hypervitaminosis A.

## Species-specific warnings

> **Caution:** Cattle: Deep IM neck only. Do not re-inject within 30 days. Useful pre-monsoon prophylaxis.

## Adverse effects

- Injection-site reaction (transient swelling)
- Hypervitaminosis A on over-dosing (skeletal changes, dermatitis)

## Pregnancy and lactation

Safe during pregnancy at recommended doses — actually beneficial peri-partum.

## Monitoring

- Spacing between injections — do not re-inject within 30 days
- Body condition / coat appearance
- Clinical response in reproductive / scours cases

## Clinical pearls

- Mid-lactation high-producing dairy cow with dull coat: 5 mL Intavita IM + multimineral bolus often restores body condition over 4–6 weeks
- Post-deworming recovery: pair AD3E injection with iron + B12 to accelerate recovery
- Reproductive support — 5 mL IM at the time of breeding has been used in repeat-breeder cows in field practice
- Vimeral oral syrup is a calf-friendly alternative when IM is logistically difficult

## Mechanism of action

Vit A (retinol) — epithelial integrity, vision, reproduction; Vit D3 (cholecalciferol) — calcium and phosphorus homeostasis via 1,25-OH vit D activation; Vit E (alpha-tocopherol) — antioxidant, membrane stabilisation, muscle function. Biotin — keratinisation of hoof, skin, hair. Depot oil-based injection releases over 30–60 days.

## Formulations and products

- Intavita 5 mL ampoule — Vit A 1.25 M IU + D3 125 K IU + E 500 IU + Biotin 62.5 mcg per 5 mL (Intas)
- Intavita Injection (Intas (Neovet)) — Vit A 250 000 IU + D3 25 000 IU + E 100 IU + Biotin 12.5 µg per mL, Oil-based depot IM injection
- Vimeral Syrup (Virbac India) — Vit A + D3 + E + B12 oral syrup, Oral syrup
- Surevet-AD3 (Assure Biotech, Jagadhri (HR)) — Vitamin A 250000 IU + Vitamin D3 25000 IU + Vitamin E 100 IU + Biotin 12.5 mcg per mL, Oily injection (sesame oil base) - IM

## Storage

15–25 °C, protect from light.

## Before you use this dose

> **Caution:** Reference doses for veterinary professionals. Confirm the dose against the product label, the patient’s condition, current guidance and local regulations before use; the attending veterinarian remains responsible for every clinical decision.

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## Frequently asked questions

### What is the dose of Vitamin AD3E Injection for cattle?

Reference doses for Vitamin AD3E Injection in cattle: 5 mL per 300 kg deep IM every 30–60 days IM q30–60 d (Prophylactic AD3E supplementation). Confirm against the label and the patient before use.

### What is the dose of Vitamin AD3E Injection for horses?

Reference doses for Vitamin AD3E Injection in horses: 5 mL per adult horse IM IM q30–60 d (Adult horse — prophylaxis). Confirm against the label and the patient before use.

### What is the dose of Vitamin AD3E Injection for goats?

Reference doses for Vitamin AD3E Injection in goats: 1–2 mL per adult goat IM IM q30–60 d (Adult goat — prophylaxis). Confirm against the label and the patient before use.

### What is the withdrawal period for Vitamin AD3E Injection?

Cattle, IM (Prophylactic AD3E supplementation): Withdrawal NOT established — treat as extra-label; Goats, IM (Adult goat — prophylaxis): Withdrawal NOT established — treat as extra-label; Sheep, IM (Adult sheep — prophylaxis): Withdrawal NOT established — treat as extra-label; Pigs, IM (Adult pig — prophylaxis): Withdrawal NOT established — treat as extra-label; Buffalo, IM (Prophylactic AD3E supplementation / fertility support): Withdrawal NOT established — treat as extra-label. Follow the product label and national regulations where they differ.

### When should Vitamin AD3E Injection not be used?

Hypervitaminosis A or D (rare in practice). Severe hepatic / renal disease (caution). DO NOT re-inject within 30 days — risk of hypervitaminosis A.

### What are the side effects of Vitamin AD3E Injection in animals?

Injection-site reaction (transient swelling); Hypervitaminosis A on over-dosing (skeletal changes, dermatitis).

## Sources

- Intas Neovet Product Catalogue — Intavita; Virbac India Cattle Catalogue — Vimeral Syrup (oral alternative)

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VetMasterJi is a clinical decision-support and education platform for veterinary professionals and students. It does not provide veterinary advice, diagnosis or treatment for specific animals. All drug doses, calculators and differentials are references that must be independently verified before clinical use; the attending registered veterinarian remains solely responsible for every clinical decision.