# Sarolaner: veterinary dose and monograph

> Sarolaner is a veterinary antiparasitic. Monthly isoxazoline flea / tick chewable with rapid onset — begins killing fleas within hours and gives sustained tick kill across the month. Indications include flea infestation — monthly control; tick infestation (Rhipicephalus, Dermacentor, Ixodes, Amblyomma); demodectic / sarcoptic mange (off-label). This monograph lists 4 reference doses for dogs, each with route, frequency and source.

Source: https://vetmasterji.com/drugs/sarolaner · Last reviewed: 2026-10-01

## At a glance

- **Drug class:** Antiparasitic
- **Also known as:** Simparica
- **Species with doses:** Dogs
- **General dose range:** 2–4 mg/kg PO monthly — check the species tables for the indication
- **Routes:** PO
- **Last reviewed:** 1 October 2026

## Indications

- Flea infestation — monthly control
- Tick infestation (Rhipicephalus, Dermacentor, Ixodes, Amblyomma)
- Demodectic / sarcoptic mange (off-label)

## Sarolaner dose by species

Doses are per administration unless stated. mg/kg doses scale with body weight; per-animal, per-quarter and infusion-rate doses are shown as the reference writes them.

### Dogs

*Sarolaner doses for dogs*

| Indication | Dose | Route | Frequency | Duration |
| --- | --- | --- | --- | --- |
| Flea / tick control | 2–4 mg/kg | PO | one chew per weight band monthly | — |
| Generalised demodicosis | 2–4 mg/kg | PO | monthly × 3–5 doses | — |
| Sarcoptic mange / Otodectes | 2–4 mg/kg | PO | 2 doses 30 days apart (Otodectes: 1 or 2) | — |
| Myiasis (New World screwworm larvae) | 2 mg/kg | PO | single dose | — |

- Flea / tick control: Papich 5e: 2 mg/kg PO once monthly (label bands 2–4 mg/kg); also used monthly for Demodex. The combination with moxidectin and pyrantel delivers 1.2 mg/kg sarolaner monthly. Plumb’s 10e p.1146 (label dosage; FDA-approved): minimum 2 mg/kg PO once a month by weight-band tablet; sarolaner/moxidectin/pyrantel provides minimum 1.2 mg/kg sarolaner + 24 µg/kg moxidectin + 5 mg/kg pyrantel monthly. Cats: neither reference gives a single-agent sarolaner dose — Plumb’s 10e covers cats only as the selamectin/sarolaner combination.
- Generalised demodicosis: Plumb’s 10e p.1146 (extra-label): 2–4 mg/kg PO; 3 to 5 monthly doses achieved parasitological cure in client-owned dogs.
- Sarcoptic mange / Otodectes: Plumb’s 10e p.1146 (extra-label): 2–4 mg/kg PO — Sarcoptes scabiei: 2 doses 30 days apart gave parasitological cure in 100% of dogs; Otodectes cynotis: 1 or 2 doses 30 days apart.
- Myiasis (New World screwworm larvae): Plumb’s 10e p.1146 (extra-label): a single 2 mg/kg dose had a 100% larvicidal effect on Cochliomyia hominivorax larvae after 24 hours.

## Contraindications

Caution in dogs with seizure disorders (isoxazoline class effect). Not established < 6 months / < 1.3 kg. Hypersensitivity.

## Species-specific warnings

> **Caution:** Dogs: Isoxazoline class — tremor / ataxia / seizures reported; caution in dogs with a seizure history.

## Adverse effects

- Vomiting, diarrhoea (mild)
- Lethargy, anorexia
- Rare neurological signs (tremor, ataxia, seizure)

## Drug interactions

- No significant interactions reported; combined with moxidectin + pyrantel in Simparica Trio
- Highly protein-bound — theoretical displacement only

## Pregnancy and lactation

Not established in breeding, pregnant or lactating dogs — avoid unless clearly needed.

## Monitoring

- Neurological status in epileptic dogs
- Monthly dosing compliance

## Toxicity and overdose

Wide safety margin; class-related neurological signs (tremor, ataxia, seizures) are possible, mainly in predisposed dogs.

## Clinical pearls

- Fast flea knockdown makes it useful in flea-allergic dogs where speed of kill matters
- Available combined with moxidectin / pyrantel (Simparica Trio) for all-in-one endo/ecto cover
- Standard isoxazoline seizure caution applies

## Mechanism of action

Isoxazoline. Selectively blocks arthropod GABA-gated (and glutamate-gated) chloride channels, producing rapid flea and tick death with minimal activity at mammalian channels.

## Formulations and products

- Simparica chewable 5–120 mg (by bodyweight band)
- Simparica (Zoetis) — 5 / 10 / 20 / 40 / 80 / 120 mg, Chewable tablet

## Storage

Store at room temperature, dry.

## Before you use this dose

> **Caution:** Reference doses for veterinary professionals. Confirm the dose against the product label, the patient’s condition, current guidance and local regulations before use; the attending veterinarian remains responsible for every clinical decision.

## Other antiparasitics

- [Pyrantel pamoate](https://vetmasterji.com/drugs/pyrantel)
- [Pyrimethamine](https://vetmasterji.com/drugs/pyrimethamine)
- [Rafoxanide](https://vetmasterji.com/drugs/rafoxanide)
- [Ronidazole](https://vetmasterji.com/drugs/ronidazole)
- [Selamectin](https://vetmasterji.com/drugs/selamectin)
- [Spinosad](https://vetmasterji.com/drugs/spinosad)
- [Toltrazuril](https://vetmasterji.com/drugs/toltrazuril)
- [Triclabendazole](https://vetmasterji.com/drugs/triclabendazole)

## Frequently asked questions

### What is the dose of Sarolaner for dogs?

Reference doses for Sarolaner in dogs: 2–4 mg/kg PO one chew per weight band monthly (Flea / tick control); 2–4 mg/kg PO monthly × 3–5 doses (Generalised demodicosis); 2–4 mg/kg PO 2 doses 30 days apart (Otodectes: 1 or 2) (Sarcoptic mange / Otodectes); 2 mg/kg PO single dose (Myiasis (New World screwworm larvae)). Confirm against the label and the patient before use.

### When should Sarolaner not be used?

Caution in dogs with seizure disorders (isoxazoline class effect). Not established < 6 months / < 1.3 kg. Hypersensitivity.

### What are the side effects of Sarolaner in animals?

Vomiting, diarrhoea (mild); Lethargy, anorexia; Rare neurological signs (tremor, ataxia, seizure).

## Sources

- Plumb's Veterinary Drug Handbook
- Papich, Papich Handbook of Veterinary Drugs, 5th edition

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VetMasterJi is a clinical decision-support and education platform for veterinary professionals and students. It does not provide veterinary advice, diagnosis or treatment for specific animals. All drug doses, calculators and differentials are references that must be independently verified before clinical use; the attending registered veterinarian remains solely responsible for every clinical decision.