# Methylcobalamin (Active B12): veterinary dose and monograph

> Methylcobalamin (Active B12) is a veterinary drug. Active form of vitamin B12 (methylated) used for neuropathy adjunct therapy — peripheral neuropathy, downer cow neuropathy, post-trauma nerve regeneration, neonatal nerve maturation support. Indications include peripheral neuropathy (downer cow, post-calving paresis nerve damage); post-trauma nerve regeneration support; adjunct in IVDD post-surgical recovery. This monograph lists 6 reference doses for dogs, cats, cattle, horses, goats and sheep, each with route, frequency and source, plus meat and milk withdrawal periods for food animals.

Source: https://vetmasterji.com/drugs/methylcobalamin-injection · Last reviewed: 2026-10-01

## At a glance

- **Drug class:** Veterinary drug
- **Also known as:** Tribivet M, Methylcobalamin Vet, Mecobalamin
- **Species with doses:** Dogs, Cats, Cattle, Horses, Goats and Sheep
- **Routes:** IM, SC
- **Last reviewed:** 1 October 2026

## Indications

- Peripheral neuropathy (downer cow, post-calving paresis nerve damage)
- Post-trauma nerve regeneration support
- Adjunct in IVDD post-surgical recovery
- Calf nutritional myodystrophy (with selenium)

## Methylcobalamin (Active B12) dose by species

Doses are per administration unless stated. mg/kg doses scale with body weight; per-animal, per-quarter and infusion-rate doses are shown as the reference writes them.

### Dogs

*Methylcobalamin (Active B12) doses for dogs*

| Indication | Dose | Route | Frequency | Duration |
| --- | --- | --- | --- | --- |
| IVDD recovery / neuropathy | 0.5–1 mL per dog IM/SC daily for 5 days, then weekly | SC | q24h × 5 d then weekly | — |

- IVDD recovery / neuropathy: Catalogue: 0.5–1 mL IM/SC daily × 5 d then weekly during recovery.

### Cats

*Methylcobalamin (Active B12) doses for cats*

| Indication | Dose | Route | Frequency | Duration |
| --- | --- | --- | --- | --- |
| Diabetic neuropathy / IBD nerve support | 0.25–0.5 mL per cat SC weekly | SC | weekly | — |

- Diabetic neuropathy / IBD nerve support: 0.25–0.5 mL SC weekly is the catalogue starting point.

### Cattle

*Methylcobalamin (Active B12) doses for cattle*

| Indication | Dose | Route | Frequency | Duration | Withdrawal |
| --- | --- | --- | --- | --- | --- |
| Downer cow neuropathy | 5–10 mL per cow IM daily for 5 days, then weekly for 4 weeks | IM | q24h × 5 d then weekly | — | Withdrawal NOT established — treat as extra-label |

- Downer cow neuropathy: Catalogue: 5–10 mL Tribivet M IM in cattle daily for 5 days then weekly for 4 weeks.

### Horses

*Methylcobalamin (Active B12) doses for horses*

| Indication | Dose | Route | Frequency | Duration |
| --- | --- | --- | --- | --- |
| Peripheral neuropathy | 5–10 mL per horse IM daily for 5 days | IM | q24h × 5 d | — |

- Peripheral neuropathy: Catalogue: 5–10 mL IM.

### Goats

*Methylcobalamin (Active B12) doses for goats*

| Indication | Dose | Route | Frequency | Duration | Withdrawal |
| --- | --- | --- | --- | --- | --- |
| Neuropathy | 1–2 mL per goat IM daily for 5 days | IM | q24h × 5 d | — | Withdrawal NOT established — treat as extra-label |

- Neuropathy: Catalogue: 1–2 mL IM.

### Sheep

*Methylcobalamin (Active B12) doses for sheep*

| Indication | Dose | Route | Frequency | Duration | Withdrawal |
| --- | --- | --- | --- | --- | --- |
| Neuropathy | 1–2 mL per sheep IM daily for 5 days | IM | q24h × 5 d | — | Withdrawal NOT established — treat as extra-label |

- Neuropathy: Catalogue: 1–2 mL IM.

### Buffalo

No buffalo-specific doses are on file, so buffalo are dosed as cattle.

*Methylcobalamin (Active B12) doses for buffalo*

| Indication | Dose | Route | Frequency | Duration | Withdrawal |
| --- | --- | --- | --- | --- | --- |
| Downer cow neuropathy | 5–10 mL per cow IM daily for 5 days, then weekly for 4 weeks | IM | q24h × 5 d then weekly | — | Withdrawal NOT established — treat as extra-label |

- Downer cow neuropathy: Catalogue: 5–10 mL Tribivet M IM in cattle daily for 5 days then weekly for 4 weeks.

## Contraindications

Hypersensitivity. No serious contraindications at recommended doses.

## Species-specific warnings

> **Caution:** Cattle: Pair with calcium + phosphorus for downer cow recovery — Tribivet M alone is insufficient.

## Adverse effects

- Pain on IM injection (transient)
- Hypersensitivity (very rare)

## Pregnancy and lactation

Safe.

## Monitoring

- Clinical neurological response over 2–4 weeks
- Body condition and appetite

## Clinical pearls

- Downer cow with sciatic nerve damage: 10 mL Tribivet M IM daily × 5 days then weekly — supportive but not curative
- Canine post-IVDD surgery: 1 mL SC daily × 5 days then weekly aids nerve recovery — pair with physiotherapy
- Cat with diabetic neuropathy: 0.25–0.5 mL SC weekly is a low-risk adjunct alongside insulin therapy
- Use BEFORE chronic nerve damage becomes irreversible — early intervention gives best results

## Mechanism of action

Methylcobalamin is the methylated, biologically active form of B12. Acts as a methyl-group donor in nerve myelin sheath maintenance and homocysteine metabolism. Penetrates nerve tissue more effectively than cyanocobalamin — preferred form for clinically established neuropathy.

## Formulations and products

- Tribivet M — Methylcobalamin 1500 µg/mL (Intas)
- Tribivet M (Intas (Neovet)) — Methylcobalamin 1500 µg/mL, IV / IM injection
- Mecocam (Assure Biotech, Jagadhri (HR)) — Methylcobalamin 500 mcg + Pyridoxine 50 mg + Niacinamide 50 mg per mL, Injection - IM or IV
- Mecob-Vet-2500 (Assure Biotech, Jagadhri (HR)) — Methylcobalamin 2500 mcg/mL, Injection - IM or IV
- Mecob-Vet Plus (Assure Biotech, Jagadhri (HR)) — Mecobalamin 500 mcg + Pyridoxine 50 mg + Niacinamide 50 mg per mL, Injection - IM or IV

## Storage

15–25 °C, protect from light.

## Before you use this dose

> **Caution:** Reference doses for veterinary professionals. Confirm the dose against the product label, the patient’s condition, current guidance and local regulations before use; the attending veterinarian remains responsible for every clinical decision.

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## Frequently asked questions

### What is the dose of Methylcobalamin (Active B12) for dogs?

Reference doses for Methylcobalamin (Active B12) in dogs: 0.5–1 mL per dog IM/SC daily for 5 days, then weekly SC q24h × 5 d then weekly (IVDD recovery / neuropathy). Confirm against the label and the patient before use.

### What is the dose of Methylcobalamin (Active B12) for cats?

Reference doses for Methylcobalamin (Active B12) in cats: 0.25–0.5 mL per cat SC weekly SC weekly (Diabetic neuropathy / IBD nerve support). Confirm against the label and the patient before use.

### What is the dose of Methylcobalamin (Active B12) for cattle?

Reference doses for Methylcobalamin (Active B12) in cattle: 5–10 mL per cow IM daily for 5 days, then weekly for 4 weeks IM q24h × 5 d then weekly (Downer cow neuropathy). Confirm against the label and the patient before use.

### What is the withdrawal period for Methylcobalamin (Active B12)?

Cattle, IM (Downer cow neuropathy): Withdrawal NOT established — treat as extra-label; Goats, IM (Neuropathy): Withdrawal NOT established — treat as extra-label; Sheep, IM (Neuropathy): Withdrawal NOT established — treat as extra-label. Follow the product label and national regulations where they differ.

### When should Methylcobalamin (Active B12) not be used?

Hypersensitivity. No serious contraindications at recommended doses.

### What are the side effects of Methylcobalamin (Active B12) in animals?

Pain on IM injection (transient); Hypersensitivity (very rare).

## Sources

- Intas Neovet Product Catalogue — Tribivet M

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VetMasterJi is a clinical decision-support and education platform for veterinary professionals and students. It does not provide veterinary advice, diagnosis or treatment for specific animals. All drug doses, calculators and differentials are references that must be independently verified before clinical use; the attending registered veterinarian remains solely responsible for every clinical decision.