Methylcobalamin (Active B12): veterinary dose and monograph

At a glance

Drug class

Veterinary drug

Also known as

Tribivet M, Methylcobalamin Vet, Mecobalamin

Species with doses

Dogs, Cats, Cattle, Horses, Goats and Sheep

Routes

IM, SC

Last reviewed

1 October 2026

Indications

• Peripheral neuropathy (downer cow, post-calving paresis nerve damage)
• Post-trauma nerve regeneration support
• Adjunct in IVDD post-surgical recovery
• Calf nutritional myodystrophy (with selenium)

Methylcobalamin (Active B12) dose by species

Doses are per administration unless stated. mg/kg doses scale with body weight; per-animal, per-quarter and infusion-rate doses are shown as the reference writes them.

Dogs

• IVDD recovery / neuropathy: Catalogue: 0.5–1 mL IM/SC daily × 5 d then weekly during recovery.

Cats

• Diabetic neuropathy / IBD nerve support: 0.25–0.5 mL SC weekly is the catalogue starting point.

Cattle

• Downer cow neuropathy: Catalogue: 5–10 mL Tribivet M IM in cattle daily for 5 days then weekly for 4 weeks.

Horses

• Peripheral neuropathy: Catalogue: 5–10 mL IM.

Goats

• Neuropathy: Catalogue: 1–2 mL IM.

Sheep

• Neuropathy: Catalogue: 1–2 mL IM.

Buffalo

No buffalo-specific doses are on file, so buffalo are dosed as cattle.

• Downer cow neuropathy: Catalogue: 5–10 mL Tribivet M IM in cattle daily for 5 days then weekly for 4 weeks.

Contraindications

Hypersensitivity. No serious contraindications at recommended doses.

Species-specific warnings

Cattle: Pair with calcium + phosphorus for downer cow recovery — Tribivet M alone is insufficient.

Adverse effects

• Pain on IM injection (transient)
• Hypersensitivity (very rare)

Pregnancy and lactation

Safe.

Monitoring

• Clinical neurological response over 2–4 weeks
• Body condition and appetite

Clinical pearls

• Downer cow with sciatic nerve damage: 10 mL Tribivet M IM daily × 5 days then weekly — supportive but not curative
• Canine post-IVDD surgery: 1 mL SC daily × 5 days then weekly aids nerve recovery — pair with physiotherapy
• Cat with diabetic neuropathy: 0.25–0.5 mL SC weekly is a low-risk adjunct alongside insulin therapy
• Use BEFORE chronic nerve damage becomes irreversible — early intervention gives best results

Mechanism of action

Methylcobalamin is the methylated, biologically active form of B12. Acts as a methyl-group donor in nerve myelin sheath maintenance and homocysteine metabolism. Penetrates nerve tissue more effectively than cyanocobalamin — preferred form for clinically established neuropathy.

Formulations and products

• Tribivet M — Methylcobalamin 1500 µg/mL (Intas)
• Tribivet M (Intas (Neovet)) — Methylcobalamin 1500 µg/mL, IV / IM injection
• Mecocam (Assure Biotech, Jagadhri (HR)) — Methylcobalamin 500 mcg + Pyridoxine 50 mg + Niacinamide 50 mg per mL, Injection - IM or IV
• Mecob-Vet-2500 (Assure Biotech, Jagadhri (HR)) — Methylcobalamin 2500 mcg/mL, Injection - IM or IV
• Mecob-Vet Plus (Assure Biotech, Jagadhri (HR)) — Mecobalamin 500 mcg + Pyridoxine 50 mg + Niacinamide 50 mg per mL, Injection - IM or IV

Storage

15–25 °C, protect from light.

Before you use this dose

Reference doses for veterinary professionals. Confirm the dose against the product label, the patient’s condition, current guidance and local regulations before use; the attending veterinarian remains responsible for every clinical decision.

Other hormones, emergency drugs, supplements and other drugs

• Megestrol Acetate
• Metformin
• Methimazole
• Methocarbamol
• Methylene Blue
• Mitotane (o,p'-DDD)
• Mycophenolate Mofetil
• N-Acetylcysteine (NAC)

Frequently asked questions